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Alternative toxicity testing. --- Alternatives in toxicity testing --- Alternatives to animal testing in toxicology --- Animal testing alternatives in toxicology --- Toxicity testing --- Toxicology --- Animal models

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This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem cells and transcriptomics, and for methods derived from pathway-based concepts in toxicology. Validation of Alternative Methods for Toxicity Testing is divided into two sections, in the first, practical insights are given on the state-of-the-art and on approaches that have resulted in successfully validated and accepted alternative methods. The second section focuses on the evolution of validation principles and practice that are necessary to ensure fit-for-purpose validation that has the greatest impact on international regulatory acceptance of alternative methods. In this context validation needs to keep pace with the considerable scientific advancements being made in toxicology, the availability of sophisticated tools and techniques that can be applied in a variety of ways, and the increasing societal and regulatory demands for better safety assessment. This book will be a useful resource for scientists in the field of toxicology, both from industry and academia, developing new test methods, strategies or techniques, as well as Governmental and regulatory authorities interested in understanding the principles and practicalities of validation of alternative methods for toxicity testing. .

Medicine. --- Molecular biology. --- Pharmaceutical technology. --- Biomedicine. --- Pharmaceutical Sciences/Technology. --- Molecular Medicine. --- Alternative toxicity testing. --- Alternatives in toxicity testing --- Alternatives to animal testing in toxicology --- Animal testing alternatives in toxicology --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Toxicity testing --- Toxicology --- Animal models

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Alternative toxicity testing --- Animal experimentation --- Animal models in research --- Medicine --- Health Workforce --- Experimentation on animals --- Zoopery --- Research --- Laboratory animals --- Alternatives in toxicity testing --- Alternatives to animal testing in toxicology --- Animal testing alternatives in toxicology --- Toxicity testing --- Toxicology --- Biological models --- Moral and ethical aspects --- Study and teaching. --- Animal models

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This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.

Medicine. --- Pharmacology. --- Dermatology. --- Animal models in research. --- Medicine & Public Health. --- Pharmacology/Toxicology. --- Animal Models. --- Alternative toxicity testing. --- Alternatives in toxicity testing --- Alternatives to animal testing in toxicology --- Animal testing alternatives in toxicology --- Toxicity testing --- Toxicology --- Animal models --- Toxicology. --- Laboratory animals. --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Skin --- Animals, Experimental --- Animals, Laboratory --- Animals in research --- Experimental animals --- Lab animals --- Animal culture --- Laboratory organisms --- Working animals --- Animal experimentation --- Diseases --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Biological models --- Laboratory animals --- Research --- Physiological effect

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Animal Testing Alternatives. --- Animals, Laboratory. --- Research Design. --- Vaccines. --- Peptide hormones --- -Toxicity testing --- -Vaccines --- -Biologicals --- Poisons --- Toxicological testing --- Toxicology --- Toxicology testing --- Toxicology, Experimental --- Hormonal peptides --- Polypeptide hormones --- Hormones --- Peptides --- Data Adjustment --- Data Reporting --- Design, Experimental --- Designs, Experimental --- Error Sources --- Experimental Designs --- Matched Groups --- Methodology, Research --- Problem Formulation --- Research Methodology --- Research Proposal --- Research Technics --- Research Techniques --- Scoring Methods --- Experimental Design --- Adjustment, Data --- Adjustments, Data --- Data Adjustments --- Design, Research --- Designs, Research --- Error Source --- Formulation, Problem --- Formulations, Problem --- Group, Matched --- Groups, Matched --- Matched Group --- Method, Scoring --- Methods, Scoring --- Problem Formulations --- Proposal, Research --- Proposals, Research --- Reporting, Data --- Research Designs --- Research Proposals --- Research Technic --- Research Technique --- Scoring Method --- Source, Error --- Sources, Error --- Technic, Research --- Technics, Research --- Technique, Research --- Techniques, Research --- Research --- Clinical Trials Data Monitoring Committees --- Laboratory Animals --- Animal, Laboratory --- Laboratory Animal --- Disease Models, Animal --- Alternatives to Animal Testing --- Alternative, Animal Testing --- Alternatives, Animal Testing --- Animal Testing Alternative --- Testing Alternative, Animal --- Testing Alternatives, Animal --- Animals, Laboratory --- Standards --- -Congresses --- Congresses --- Testing --- methods --- Biomedical Research --- -Standards --- Toxicity testing --- Vaccines --- Animal Testing Alternatives --- Research Design --- Research Strategy --- Research Strategies --- Strategies, Research --- Strategy, Research --- Biologicals --- Standards&delete& --- Proefdieren / in de farmacologie. (Congres) --- Proefdieren. Bescherming. (Congres) --- Animaux de laboratoire / en biomédecine. (Congrès) --- Animaux de laboratoire / en pharmacologie. (Congrès) --- Animaux de laboratoire. Protection. (Congrès) --- Proefdieren / in de biogeneeskunde (Congres) --- Vaccine